5-[5-[(Z)-[1-(3-carboxyphenyl)-3-methyl-5-oxopyrazol-4-ylidene]methyl]furan-2-yl]-2-chlorobenzoic acid

Names

[ CAS No. ]:
292065-64-6

[ Name ]:
5-[5-[(Z)-[1-(3-carboxyphenyl)-3-methyl-5-oxopyrazol-4-ylidene]methyl]furan-2-yl]-2-chlorobenzoic acid

[Synonym ]:
x80
hms598c17

Biological Activity

[Description]:

TDRL-X80 is a potent inhibitor of xeroderma pigmentosum group A (XPA) protein. TDRL-X80 inhibits XPA’s DNA binding activity. TDRL-X80 exhibits activity against single, double, and Cisplatin-damaged DNA with IC50s of 18, 20, and 29 μM in fluorescence polarization (FP) analyses , and with IC50s of 21, 39, and 28 in ELISA Analysis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[References]

[1]. Tracy M Neher, et al. Identification of novel small molecule inhibitors of the XPA protein using in silico based screening. ACS Chem Biol. 2010 Oct 15;5(10):953-65.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₅ClN₂O₆

[ Molecular Weight ]:
450.82800

[ Exact Mass ]:
450.06200

[ PSA ]:
120.41000

[ LogP ]:
4.30310

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H413

[ RIDADR ]:
NONH for all modes of transport

Articles

Biochemistry and Cell Wall Changes Associated with Noni (Morinda citrifolia L.) Fruit Ripening.

J. Agric. Food Chem. 64 , 302-9, (2016)

Quality and compositional changes were determined in noni fruit harvested at five ripening stages, from dark-green to thaslucent-grayish. Fruit ripening was accompanied by acidity and soluble solids a...

Race/ethnicity and potential suicide misclassification: window on a minority suicide paradox?

BMC Psychiatry 10 , 35, (2010)

Suicide officially kills approximately 30,000 annually in the United States. Analysis of this leading public health problem is complicated by undercounting. Despite persisting socioeconomic and health...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.