AD4

Names

[ Name ]:
AD4

Biological Activity

[Description]:

AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Signaling Pathways >> PROTAC >> PROTAC

[Target]

IC50: 0.6 nM (PCLAF/KIAA0101)[1]

[References]

[1]. Li Y, et al. Facilitated Drug Repurposing with Artemisinin-Derived PROTACs: Unveiling PCLAF as a Therapeutic Target. J Med Chem. 2023 Aug 24;66(16):11335-11350..

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₅H₇₈N₄O₁₅

[ Molecular Weight ]:
1035.23

Related Compounds

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