PG 116800

Names

[ Name ]:
PG 116800

Biological Activity

[Description]:

PG 116800 (PG 530742) is an orally avtive MMP inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[References]

[1]. Piotr Krzeski, et al. Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study. Arthritis Res Ther. 2007;9(5):R109.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₇N₃O₇S

[ Molecular Weight ]:
501.55200

[ Exact Mass ]:
501.15700

[ PSA ]:
146.14000

[ LogP ]:
3.19830

Related Compounds

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