Anticancer agent 101

Anticancer agent 101 is a derivative of tetracaine. Anticancer agent 101 has anti-cancer activity[1].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Anticancer agent 101 (compound 2m; 24 and 48 h) 具有抗肿瘤活性，对 Colo-205 和 HepG2 细胞的 IC50 值分别为 20.5 μM 和 62.9 μM[ 1]. Anticancer agent 101 (25 µM 和 50 µM; 24 h) 下调了 Colo-205 细胞中凋亡蛋白 PI3K 和 FoXO3a 的表达水平，上调了 PTEN 和 FoXO1 的表达水平。 Cell Viability Assay[1] Cell Line: Colo-205 and HepG2 cells Concentration: 12.5, 25, 50, 100, 200, and 400 µM Incubation Time: 24 and 48 hours Result: Inhibited cell growth in a dose-dependent manner. Western Blot Analysis[1] Cell Line: Colo-205 cell Concentration: 25 µM and 50 µM Incubation Time: 24 hours Result: Down-regulated the expression level of apoptotic protein PI3K and FoXO3a, up-regulated the expression level of PTEN and FoXO1 in Colo-205 cells

[1]. M İhsan Han, et al. Design, Synthesis, and Anticancer Evaluation of Novel Tetracaine Hydrazide-Hydrazones. ACS Omega. 2023 Feb 28;8(10):9198-9211.