2914922-80-6
2914922-80-6 structure
- Name: Anticancer agent 101
- Chemical Name: Anticancer agent 101
- CAS Number: 2914922-80-6
- Molecular Formula: C19H20F3N3O
- Molecular Weight: 363.38
- Catalog: Research Areas Cancer
- Create Date: 2023-07-09 05:09:08
- Modify Date: 2024-09-17 19:45:16
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Anticancer agent 101 is a derivative of tetracaine. Anticancer agent 101 has anti-cancer activity[1].
| Name | Anticancer agent 101 |
|---|
| Description | Anticancer agent 101 is a derivative of tetracaine. Anticancer agent 101 has anti-cancer activity[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Anticancer agent 101 (compound 2m; 24 and 48 h) 具有抗肿瘤活性，对 Colo-205 和 HepG2 细胞的 IC50 值分别为 20.5 μM 和 62.9 μM[ 1]. Anticancer agent 101 (25 µM 和 50 µM; 24 h) 下调了 Colo-205 细胞中凋亡蛋白 PI3K 和 FoXO3a 的表达水平，上调了 PTEN 和 FoXO1 的表达水平。 Cell Viability Assay[1] Cell Line: Colo-205 and HepG2 cells Concentration: 12.5, 25, 50, 100, 200, and 400 µM Incubation Time: 24 and 48 hours Result: Inhibited cell growth in a dose-dependent manner. Western Blot Analysis[1] Cell Line: Colo-205 cell Concentration: 25 µM and 50 µM Incubation Time: 24 hours Result: Down-regulated the expression level of apoptotic protein PI3K and FoXO3a, up-regulated the expression level of PTEN and FoXO1 in Colo-205 cells |
| References |
| Molecular Formula | C19H20F3N3O |
|---|---|
| Molecular Weight | 363.38 |