Anticancer agent 103

Anticancer agent 103 (Compound 2k) is a potent anticancer agent[1].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Anticancer agent 103 (Compound 2k; 12.5-400 μM; 24 or 48 h) 抑制 HepG2 细胞活力，但不抑制 Colo-205 细胞活力[1]。 Anticancer agent 103 (25 and 50 μM; 24 h) 增加 HepG2 细胞中 FoXO1、TXNIP 和 p27 蛋白水平[1]。 Cell Viability Assay[1] Cell Line: HepG2 and Colo-205 cells Concentration: 12.5, 25, 50, 100, 200 and 400 μM Incubation Time: 24 or 48 h Result: Demonstrated anticancer activity against cancer cell line HepG2 with IC50s of 30.5 μM and 14.8 μM for 24h and 48 h, respectively. The IC50 for Colo-205 was >400 μM. Western Blot Analysis[1] Cell Line: HepG2 cells Concentration: 25 and 50 μM Incubation Time: 24 h Result: Increased the FoXO1, TXNIP and p27 protein levels.

[1]. Han Mİ, et al. Design, Synthesis, and Anticancer Evaluation of Novel Tetracaine Hydrazide-Hydrazones. ACS Omega. 2023 Feb 28;8(10):9198-9211.