LSD1-IN-27

Names

[ Name ]:
LSD1-IN-27

Biological Activity

[Description]:

LSD1-IN-27 (Compound 5ac) is a LSD1 inhibitor (IC50: 13 nM). LSD1-IN-27 inhibits the stemness and migration of gastric cancer cells. LSD1-IN-27 also reduces the expression of PD-L1 in BGC-823 and MFC cells. LSD1-IN-27 can enhance T cell immune response in gastric cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Demethylase

Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1

[Target]

13 nM (LSD1)[1]

[References]

[1]. Dai XJ, et al. Novel acridine-based LSD1 inhibitors enhance immune response in gastric cancer. Eur J Med Chem. 2023 Nov 5;259:115684.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₅N₃

[ Molecular Weight ]:
355.48

Related Compounds

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