Antifungal agent 52

Names

[ Name ]:
Antifungal agent 52

Biological Activity

[Description]:

Antifungal agent 52 (compound 6c) is a tetrazole derivative. Antifungal agent 52 inhibits the synthesis of Ergosterol (HY-N0181). Antifungal agent 52 exhibit a significant antifungal activity against Candida albicans. Antifungal agent 52 affects C. albicans sessile cell membrane permeabilization[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Antifungal agent 52 (compound 6c) (16 μg/mL, 18 h) 处理的细胞进入G0/G1期（代谢状态/细胞增殖）以维持子细胞[1]。 Antifungal agent 52 在 >64 μg/mL 时显示出显着毒性，并且对口腔癌细胞系 TR146 没有毒性[1]。

[References]

[1]. Staniszewska M, et al. Tetrazole derivatives bearing benzodiazepine moiety-synthesis and action mode against virulence of Candida albicans. Eur J Med Chem. 2022 Feb 15;230:114060.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₁₉BrClFN₆O

[ Molecular Weight ]:
553.81

Related Compounds

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