Antifungal agent 51

Antifungal agent 51 (5c) has potent antifungal activity, especially against Candida albicans FDC 151 , Candida parapsilosis ATCC 22019 and Candida tropicalis FDC 138, with the MIC value is less than 0.063 μg/mL, and it has low toxicity to cells and no carcinogenicity[1].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Antifungal agent 51 具有很强的抗真菌活性，尤其是对白色念珠菌 FDC 151、近平滑念珠菌 ATCC 22019 和热带念珠菌 FDC 138，具有 MIC 值 小于 0.063 μg/mL，对白色念珠菌 CMRC 19 和光滑念珠菌FDC 192，MIC 值为 0.125 μg/mL，对白色念珠菌 CMRC 192，MIC 值为 0.25 μg/mL，对抗光滑念珠菌 CMRC 89，MIC 值为 1 μg/mL[1]。 Antifungal agent 51（6.25、12.5、25 μg/mL；48 小时）在 BEAS-2B 和 HepG2 细胞中即使在 25 μg/mL 的相对高浓度下也会部分影响细胞系的活力[1]。 Cell Viability Assay[1] Cell Line: BEAS-2B and HepG2 cells Concentration: 6.25, 12.5, and 25 μg/mL Incubation Time: 48 h Result: Partially affected the viability of cell lines even at relatively high concentration of 25 μg/mL in BEAS-2B and HepG2 cells

[1]. Ghobadi E, et al. Design, synthesis and biological activity of hybrid antifungals derived from fluconazole and mebendazole. Eur J Med Chem. 2023 Mar 5;249:115146.