RUNX-IN-2

Names

[ Name ]:
RUNX-IN-2

Biological Activity

[Description]:

RUNX-IN-2 (Compound Conjugate 3) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-2 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-2 inhibits tumor growth in PANC-1 xenograft mice. RUNX-IN-2 has high alkylation efficiency and specificity[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[Target]

RUNX[1]

[References]

[1]. Hirose Y, et al. Anticancer Activities of DNA-Alkylating Pyrrole-Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53-Mutated Pancreatic Cancer PANC-1 Cells. J Med Chem. 2023 Sep 14;66(17):12059-12068.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇₁H₈₈Cl₂N₂₄O₁₁

[ Molecular Weight ]:
1524.52

Related Compounds

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