2893777-88-1

2893777-88-1 structure

Name: RUNX-IN-2
Chemical Name: RUNX-IN-2
CAS Number: 2893777-88-1
Molecular Formula: C₇₁H₈₈Cl₂N₂₄O₁₁
Molecular Weight: 1524.52
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-11-04 14:54:27
Modify Date: 2024-01-04 23:40:08
RUNX-IN-2 (Compound Conjugate 3) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-2 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-2 inhibits tumor growth in PANC-1 xenograft mice. RUNX-IN-2 has high alkylation efficiency and specificity[1].

Name	RUNX-IN-2

Description	RUNX-IN-2 (Compound Conjugate 3) covalently binds to the RUNX-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-2 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-2 inhibits tumor growth in PANC-1 xenograft mice. RUNX-IN-2 has high alkylation efficiency and specificity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	RUNX[1]
References	[1]. Hirose Y, et al. Anticancer Activities of DNA-Alkylating Pyrrole-Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53-Mutated Pancreatic Cancer PANC-1 Cells. J Med Chem. 2023 Sep 14;66(17):12059-12068.

Molecular Formula	C₇₁H₈₈Cl₂N₂₄O₁₁
Molecular Weight	1524.52