P-gp inhibitor 14

Names

[ CAS No. ]:
2892571-47-8

[ Name ]:
P-gp inhibitor 14

Biological Activity

[Description]:

P-gp inhibitor 14 (Compound 8a) is a high affinity P-gp inhibitor. P-gp inhibitor 14 reverses P-gp-mediated multidrug resistance (EC50=48.74 nM). P-gp inhibitor 14 has a weak inhibitory effect on CYP3A4 activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[References]

[1]. Jiang C, et al. Design and evaluation of dibenzoazepine-tetrahydroisoquinoline hybrids as potential P-glycoprotein inhibitors against multidrug resistant K562/A02 cells. Eur J Med Chem. 2023 Mar 5;249:115150.  

Chemical & Physical Properties

[ Molecular Formula ]:
C37H38N2O8

[ Molecular Weight ]:
638.71

Related Compounds