pan-KRAS-IN-4

Names

[ Name ]:
pan-KRAS-IN-4

Biological Activity

[Description]:

pan-KRAS-IN-4 (compound 5) is a potent inhibitor of KRAS with IC50s of 0.37 nM (Kras G12C), 0.19 nM (Kras G12V), respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

IC50: 0.37 nM (Kras G12C), 0.19 nM (Kras G12V)

[References]

[1]. Chen Y, et al. Synthesis of Mutant KRAS modulators treating neoplastic, autoimmune diseases, and inflammatory disorders. World Intellectual Property Organization, WO2022271823 A1 2022-12-29.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₆H₃₄F₂N₆O₃

[ Molecular Weight ]:
636.69

Related Compounds

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