Tyrosinase-IN-10

Names

[ Name ]:
Tyrosinase-IN-10

Biological Activity

[Description]:

Tyrosinase-IN-10 (Compound 23) is a partially competitive tyrosinase inhibitor with an IC50 of 1.6 μM against tyrosinase activity from human melanoma cell lysates[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[Target]

IC50: 1.6 μM (human tyrosinase)[1]

[In Vitro]

Tyrosinase-IN-10 (Compound 23) (0-100 μM; 96 h) 抑制 MNT-1 全细胞黑素生成，IC50 为 29 μM, 对 MNT-1 的细胞毒性 CC50 为 91 μM[1]。 Cell Cytotoxicity Assay[1] Cell Line: MNT-1 cells Concentration: 0-100 μM Incubation Time: 96 h Result: Showed cytotoxicity with a CC50 of 91 μM.

[References]

[1]. Roulier B, et al. Resorcinol-based hemiindigoid derivatives as human tyrosinase inhibitors and melanogenesis suppressors in human melanoma cells. Eur J Med Chem. 2023 Jan 15;246:114972.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₂O₄

[ Molecular Weight ]:
268.26

Related Compounds

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