Mtb-IN-2

Names

[ Name ]:
Mtb-IN-2

Biological Activity

[Description]:

Mtb-IN-2 (compound 10c) is an antimicrobial agent against Mycobacterium tuberculosis (Mtb), without cytotoxicity. Mtb-IN-2 significantly decreases colony-forming units (CFU) in spleen of murine tuberculosis models, and distinguishes both drug-sensitive and drug-resistant Mtb H37Rv strains. Mtb-IN-2 affects methionine metabolism but not folate pathway directly.

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Nawrot DE, et al. Antimycobacterial pyridine carboxamides: From design to in vivo activity. Eur J Med Chem. 2023 Oct 5;258:115617.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₂N₂O₄

[ Molecular Weight ]:
308.29

Related Compounds

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