Sigma-2 Radioligand 1

Names

[ Name ]:
Sigma-2 Radioligand 1

Biological Activity

[Description]:

Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice and good in vivo activity in rats. [18F] Modified Sigma-2 Radioligand 1 for visualization of tumors in micro-PET/CT imaging, exhibiting high tumor uptake and tumor-to-background ratio. Experiments show that Sigma-2 Radioligand 1 binds highly specifically in U87MG glioma xenografts[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Sigma Receptor

[Target]

Ki: 2.57 nM (Sigma-2, σ2)[1]

[References]

[1]. Wang T, et al. Development of a Highly Specific 18F-Labeled Radioligand for Imaging of the Sigma-2 Receptor in Brain Tumors. J Med Chem. 2023 Sep 13.. .

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₃₀FN₃O₃

[ Molecular Weight ]:
427.51