Tentoxin

Names

[ Name ]:
Tentoxin

[Synonym ]:
12-benzylidene-3-isobutyl-1,6,7-trimethyl-1,4,7,10-tetraaza-cyclododecane-2,5,8,11-tetraone
1,4,7,10-Tetraazacyclododecane-2,5,8,11-tetrone, 1,6,7-trimethyl-3-(2-methylpropyl)-12-(phenylmethylene)-, (3S,6S,12Z)-
Cycloleucyl-N-methylalanylglycyl-N-methyl dehydrophenylalanine
(3S,6S,12Z)-12-Benzylidene-3-isobutyl-1,6,7-trimethyl-1,4,7,10-tetraazacyclododecane-2,5,8,11-tetrone
tentoxin

Biological Activity

[Description]:

Tentoxin is a cyclic tetrapeptide isolated from Alternaria tenuis, acts as a herbicide, causes seedling chlorosis, inhibits cyclic photophosphorylation and functions as an energy transfer inhibitor[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Arntzen CJ. Inhibition of photophosphorylation by tentoxin, a cyclic tetrapeptide. Biochim Biophys Acta. 1972 Dec 14;283(3):539-42.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
750.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₃₀N₄O₄

[ Molecular Weight ]:
414.498

[ Flash Point ]:
407.9±32.9 °C

[ Exact Mass ]:
414.226715

[ PSA ]:
98.82000

[ LogP ]:
1.24

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.528

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
29337900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

[Simultaneous determination of four Alternaria toxins in apple juice concentrate by ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry].

Se Pu 28(12) , 1128-31, (2010)

An ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/ MS) method was developed for the determination of altenuene (ALT), alternariol (AOH), tentoxin and alternariol monomethyl ...

Hybrid Rhodospirillum rubrum F(0)F(1) ATP synthases containing spinach chloroplast F(1) beta or alpha and beta subunits reveal the essential role of the alpha subunit in ATP synthesis and tentoxin sensitivity.

J. Biol. Chem. 275(2) , 906-12, (2000)

Trace amounts ( approximately 5%) of the chloroplast alpha subunit were found to be absolutely required for effective restoration of catalytic function to LiCl-treated chromatophores of Rhodospirillum...

Structure-activity relationships of cyclotetrapeptides: interaction of tentoxin derivatives with three membrane proteins.

Adv. Exp. Med. Biol. 500 , 343-6, (2001)