10-Formyl-7,8-dihydrofolic acid

Names

[ CAS No. ]:
28459-40-7

[ Name ]:
10-Formyl-7,8-dihydrofolic acid

[Synonym ]:
10-Formyl-7,8-dihydro Folic Acid
(2S)-2-[[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid

Biological Activity

[Description]:

10-Formyl-7,8-dihydrofolic acid is a substrate for mammalian aminoimidazolecarboxamide ribotide transformylase (EC 2.1.2.3). 10-Formyl-7,8-dihydrofolic acid also is a metabolite of 10-HCO-H4folate[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Baggott JE, et al. Iron compounds catalyze the oxidation of 10-formyl-5,6,7,8 tetrahydrofolic acid to 10-formyl-7,8 dihydrofolic acid. J Inorg Biochem. 1998 Sep;71(3-4):181-7.  

[2]. Baggott JE, et al. Metabolism of 10-formyldihydrofolate in humans. Biomed Pharmacother. 2001 Oct;55(8):454-7.  

Chemical & Physical Properties

[ Density]:
1.67g/cm3

[ Molecular Formula ]:
C20H21N7O7

[ Molecular Weight ]:
471.42300

[ Exact Mass ]:
471.15000

[ PSA ]:
221.16000

[ LogP ]:
0.50370

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds