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Forodesine (hydrochloride)

Names

[ CAS No. ]:
284490-13-7

[ Name ]:
Forodesine (hydrochloride)

[Synonym ]:
Forodesine hydrochloride
Forodesine HCl
UNII-6SN82Y9U73
4H-Pyrrolo(3,2-d)pyrimidin-4-one,7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl)-1,5-dihydro-,monohydrochloride
BCX-1777
Forodesine hydrochloride (JAN/USAN)
Forodesine (hydrochloride)

Biological Activity

[Description]:

Forodesine hydrochloride is a potent and oral purine nucleoside phosphorylase (PNP) inhibitor with IC50s ranging from 0.48 to 1.57 nM.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Cancer

[References]

[1]. Homminga I, et al. In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia. Blood. 2011 Aug 25;118(8):2184-90.

[2]. Ogura M, et al. Phase I study of BCX1777 (forodesine) in patients with relapsed or refractory peripheral T/natural killer-cell malignancies. Cancer Sci. 2012 Jul;103(7):1290-5.

[3]. Bieghs L, et al. The effects of forodesine in murine and human multiple myeloma cells. Adv Hematol. 2010;2010:131895.

[4]. Yamauchi T, et al. A nelarabine-resistant T-lymphoblastic leukemia CCRF-CEM variant cell line is cross-resistant to the purine nucleoside phosphorylase inhibitor forodesine. Anticancer Res. 2014 Sep;34(9):4885-92.

[Related Small Molecules]

Azacitidine (5-Azacytidine) | Broxuridine | Floxuridine | Raltitrexed | Trifluorothymidine | Vidarabine | Tipiracil hydrochloride | Clofarabine | Doxifluridine | Nelarabine | 8-Azaguanine | RX-3117 | Tegafur | LY2334737 | Carmofur

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₅ClN₄O₄

[ Molecular Weight ]:
302.71400

[ Exact Mass ]:
302.07800

[ PSA ]:
134.52000

[ Storage condition ]:
2-8℃

Related Compounds