RDN2150

Names

[ Name ]:
RDN2150

Biological Activity

[Description]:

RDN2150 (Compound 25) is a ZAP-70 inhibitor (IC50: 14.6 nM). RDN2150 covalently binds to the C346 residue of ZAP-70. RDN2150 inhibits the expression of CD25 and CD69, and inhibits CD4+ T cell activation. RDN2150 can be used for research of psoriasis[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

14.6 nM (ZAP-70)[1]

[References]

[1]. Rao D, et al. Discovery and Structural Optimization of Covalent ZAP-70 Kinase Inhibitors against Psoriasis. J Med Chem. 2023 Aug 18.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₂₉ClN₈O₄

[ Molecular Weight ]:
577.03

Related Compounds

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