H-Leu-Ser-Lys-Leu-NH2 trifluoroacetate salt
Names
[ CAS No. ]:
283609-79-0
[ Name ]:
H-Leu-Ser-Lys-Leu-NH2 trifluoroacetate salt
[Synonym ]:
L-Leucinamide, L-leucyl-L-seryl-L-lysyl-
L-Leucyl-L-seryl-L-lysyl-L-leucinamide
H-Leu-Ser-Lys-Leu-NH2
LSKL, Inhibitor of Thrombospondin (TSP-1)
Biological Activity
[Description]:
LSKL, Inhibitor of Thrombospondin (TSP-1) is a peptide derived from the latency-associated peptide, inhibits thrombospondin (TSP-1) activation of TGF-β and prevents the progression of hepatic damage and fibrosis.
[Related Catalog]:
[In Vitro]
LSKL peptide is able to reduce liver fibrosis by inhibiting TGF-β activation[2].
[In Vivo]
LSKL (1 mg/kg, i.p.) can easily traverse the blood brain barrier. LSKL peptide also alleviates hydrocephalus and improves long-term cognitive function following SAH. Moreover, LSKL peptide inhibits subarachnoid fibrosis after SAH. LSKL treatment significantly decreases the activation of TGF-β1 in the CSF in comparison with that in the SAH+PBS group[1]. LSKL peptide (30 mg/kg, i.p.) successfully inhibits transforming growth factor (TGF) β-Smad signal activation induced by partial hepatectomy. LSKL peptide successfully attenuates TGF-β-Smad signal activation by antagonizing TSP-1, but not by reducing TSP-1 protein expression. LSKL peptide accelerates hepatocyte proliferation after hepatectomy[3].
[Animal admin]
Wild-type 8–12-week-old male mice (C57BL/6) are used for all experiments. LSKL TSP-1 inhibitory peptide is diluted to 5 mg/mL with normal saline. In the LSKL peptide group, LSKL peptide (30 mg/kg bodyweight in 6 mL/kg) is administered intraperitoneally before abdominal wall closure and at 6 h after the 70 per cent hepatectomy. In the normal saline group, saline (6 mL/kg) is given intraperitoneally at the same time points. In the sham-operated group, laparotomy is performed and the incision is sutured after normal saline (6 mL/kg) have been administered intraperitoneally.
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
817.8±65.0 °C at 760 mmHg
[ Molecular Formula ]:
C21H42N6O5
[ Molecular Weight ]:
458.595
[ Flash Point ]:
448.4±34.3 °C
[ Exact Mass ]:
458.321655
[ LogP ]:
-0.49
[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.521
[ Storage condition ]:
-20°C