SIRT5 inhibitor 6

Names

[ CAS No. ]:
2834736-82-0

[ Name ]:
SIRT5 inhibitor 6

Biological Activity

[Description]:

SIRT5 Inhibitor 6 is a potent, substrate-competitive and selective SIRT5 inhibitor with an IC50 of 3.0 μM. SIRT5 Inhibitor6 has a therapeutic potential against septic AKI in vivo[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Research Areas >> Inflammation/Immunology

[References]

[1]. Luohe Mou, et al, Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury. J Med Chem. 2023 Aug 24;66(16):11517-11535.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H28N6O4S

[ Molecular Weight ]:
460.55

Related Compounds

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