6-Oxochelerythrine

Names

[ Name ]:
6-Oxochelerythrine

[Synonym ]:
oxotoddaline
[1,3]Benzodioxolo[5,6-c]phenanthridin-13(12H)-one, 1,2-dimethoxy-12-methyl-
Oxychelerythrine
oxychelerytrine
Dihydrooxochelerythrine
Chelerythrine,12,13-dihydro-13-oxo
1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-13(12H)-one
6-Oxochelerythrine

Biological Activity

[Description]:

Oxychelerythrine is an alkaloid that can be isolated from Zanthoxylum integrifoliolum. Oxychelerythrine exhibits cytotoxicity against P-388 and HT-29 cell lines with ED50s of 3.25 and 5.48 μg/mL, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Chen, J.-J., et al. New Indolopyridoquinazoline, Benzo[c]phenanthridines and Cytotoxic Constituents fromZanthoxylum integrifoliolum . Planta Medica, 71(5), 470–475.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
615.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₇NO₅

[ Molecular Weight ]:
363.36

[ Flash Point ]:
326.1±31.5 °C

[ Exact Mass ]:
363.110687

[ PSA ]:
58.92000

[ LogP ]:
3.38

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.669

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FL9220000

CHEMICAL NAME :: Chelerythrine, 12,13-dihydro-13-oxo-

CAS REGISTRY NUMBER :: 28342-33-8

BEILSTEIN REFERENCE NO. :: 0345198

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H17-N-O5

MOLECULAR WEIGHT :: 363.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 125 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,267,1990

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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