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Angoline

Names

[ CAS No. ]:
21080-31-9

[ Name ]:
Angoline

[Synonym ]:
12,13-dihydro-13-methoxychelerythrine
8-methoxydihydrochelerythrine
Angoline
6-methoxy-5,6-dihydrochelerythrine

Biological Activity

[Description]:

Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> STAT

[Target]

IC50: 11.56 μM (IL6/STAT3 signaling pathway)


[References]

[1]. Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
555.5ºC at 760 mmHg

[ Molecular Formula ]:
C22H21NO5

[ Molecular Weight ]:
379.40600

[ Flash Point ]:
164.1ºC

[ Exact Mass ]:
379.14200

[ PSA ]:
49.39000

[ LogP ]:
4.41250

[ Vapour Pressure ]:
2.23E-12mmHg at 25°C

[ Index of Refraction ]:
1.678

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds