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L-Glyceric acid

Names

[ CAS No. ]:
28305-26-2

[ Name ]:
L-Glyceric acid

[Synonym ]:
(2s)-2,3-dihydroxypropanoic acid
l-glyceric acid

Biological Activity

[Description]:

L-Glyceric acid is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid excretion to distinguish PH1 from PH2[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

Human Endogenous Metabolite


[In Vitro]

Primary hyperoxaluria type 2 (PH2), also called L-glyceric aciduria. The metabolic defect is due to deficiencies of D-glycerate dehydrogenase and glyoxylate reductase, leading to excretion of L-Glyceric acid, and L-Glyceric acid is the cornerstone for the diagnosis of PH2[1][2].

[References]

[1]. Mohamed S Rashed, et al. Chiral liquid chromatography tandem mass spectrometry in the determination of the configuration of glyceric acid in urine of patients with D-glyceric and L-glyceric acidurias. Biomed Chromatogr. 2002 May;16(3):191-8.

[2]. Bernd Hoppe, et al. A United States survey on diagnosis, treatment, and outcome of primary hyperoxaluria. Pediatr Nephrol. 2003 Oct;18(10):986-91.

Chemical & Physical Properties

[ Molecular Formula ]:
C3H6O4

[ Molecular Weight ]:
106.07700

[ Exact Mass ]:
106.02700

[ PSA ]:
77.76000

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds