AB-729 sodium

Names

[ Name ]:
AB-729 sodium

Biological Activity

[Description]:

AB-729 sodium is a siRNA specifically designed to inhibit viral replication and reduces HBV antigens[1][2]. AB-729 conjugates to a trimer of N-acetylgalactosamine (GalNAc) ligand that promotes uptake into hepatocytes via the asialoglycoprotein receptor (ASGR).

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

[References]

[1]. Efthymios P Tsounis, et al. Toward a new era of hepatitis B virus therapeutics: The pursuit of a functional cure. World J Gastroenterol. 2021 Jun 7;27(21):2727-2757.

[2]. Arbutus Receives Authorization to Proceed with an Investigational New Drug Application (IND) for AB-729, its Proprietary Subcutaneously-Delivered RNAi Agent.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅₀₂H₆₄₀F₆N₁₆₂Na₃₈O₃₀₃P₃₈S₆

[ Molecular Weight ]:
16148.44

Related Compounds

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