Piperidine,2-[(2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl]-, (2S)-

Names

[ Name ]:
Piperidine,2-[(2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl]-, (2S)-

[Synonym ]:
CL-1848C
Piperidine,3-dioxolan-4-yl)
ETOXADROL

Biological Activity

[Description]:

Etoxadrol is a potent N-methyl-D-aspartic acid (NMDA) antagonist with high affinity. Etoxadrol can be used for anaesthetic research[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

NMDA[1]

[In Vivo]

Etoxadrol (100.0 mg/kg; i.h.; 30 min) produces marked stimulation and ataxia in mice[2]. Animal Model: Carworth-Farm (Upjohn) male mice weighing 18 to 20 gm[2] Dosage: 100.0 mg/kg Administration: Subcutaneous injection, 30 min Result: Produced marked stimulation and ataxia.

[References]

[1]. A Thurkauf, et al. Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. J Med Chem. 1988 Dec;31(12):2257-63.

[2]. A H Tang, et al. Analgetic activities of etoxadrol in the rhesus monkey and in mice. Anesth Analg. 1973 Jul-Aug;52(4):577-83.

Chemical & Physical Properties

[ Density]:
1.057g/cm3

[ Boiling Point ]:
373ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₂₃NO₂

[ Molecular Weight ]:
261.35900

[ Flash Point ]:
157.4ºC

[ Exact Mass ]:
261.17300

[ PSA ]:
30.49000

[ LogP ]:
3.13570

[ Index of Refraction ]:
1.52

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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