(1S,3S,7S,10R,11S,12S,16R)-3-[(1E)-2-[2-(Aminomethyl)-4-thiazolyl]-1-methylethenyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Names

[ Name ]:
(1S,3S,7S,10R,11S,12S,16R)-3-[(1E)-2-[2-(Aminomethyl)-4-thiazolyl]-1-methylethenyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

[Synonym ]:
4,17-Dioxabicyclo(14.1.0)heptadecane-5,9-dione,3-((1E)-2-(2-(aminomethyl)-4-thiazolyl)-1-methylethenyl)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-,(1S,3S,7S,10R,11S,12S,16R)
(1S,3S(E),7S,10R,11S,12S,16R)-3-[2-(2-aminomethyl-thiazol-4-yl)-1-methyl-vinyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione
21-aminoepothilone B

Biological Activity

[Description]:

BMS 310705 (21-Aminoepothilone B) is an analog of Epothilone B (HY-17029), targeting to malignancies such as ovarian, renal, bladder, and lung carcinoma. BMS 310705 induces significant apoptosis via mitochondrial-mediated pathway[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

BMS 310705 (0.01-0.5 μM; 1 h) 诱导 OC-2 细胞凋亡[1]。 BMS 310705 (-0.5 μM; 1 h) 增加 caspase-9/-3 的活性，并导致细胞色素 c 释放[1]。 Apoptosis Analysis[1] Cell Line: OC-2 cells Concentration: 0.01 μM, 0.025 μM, 0.05 μM, and 0.5 μM Incubation Time: 1 hour; reincubation in drug-free media at 24-, 48-, 72-, and 96-h intervals Result: Induced maximal cell apoptosis at 0.05 μM, and exhibited time-dependent manner.

[References]

[1]. Uyar D, et al. Apoptotic pathways of epothilone BMS 310705. Gynecol Oncol. 2003 Oct;91(1):173-8.

Chemical & Physical Properties

[ Density]:
1.16

[ Molecular Formula ]:
C₂₇H₄₂N₂O₆S

[ Molecular Weight ]:
522.69700

[ Exact Mass ]:
522.27600

[ PSA ]:
163.51000

[ LogP ]:
4.32810