VUF 5574

Names

[ CAS No. ]:
280570-45-8

[ Name ]:
VUF 5574

[Synonym ]:
VUF 5574
Lopac-V-5888

Biological Activity

[Description]:

VUF-5574 is a selective antagonist of adenosine A3 receptor with a Ki of 4.03 nM for the recombinant human receptor[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

Recombinant Human Adenosine A3 receptor (A3R):4.03 nM (Ki)

[References]

[1]. van Muijlwijk-Koezen JE, et al. Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A(3) receptor. J Med Chem. 2000 Jun 1;43(11):2227-38.

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
444.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₇N₅O₂

[ Molecular Weight ]:
371.39200

[ Flash Point ]:
222.8ºC

[ Exact Mass ]:
371.13800

[ PSA ]:
89.03000

[ LogP ]:
4.49040

[ Vapour Pressure ]:
4.14E-08mmHg at 25°C

[ Index of Refraction ]:
1.725

Safety Information

[ Safety Phrases ]:
22-24/25

Related Compounds

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