c-Myc inhibitor 9

Names

[ CAS No. ]:
2799717-96-5

[ Name ]:
c-Myc inhibitor 9

Biological Activity

[Description]:

c-Myc inhibitor 9 (compound 332) is a c-Myc inhibitor with an logEC50 of ≥6. c-Myc inhibitor 9 inhibits tumor growth in nude mouse models. c-Myc inhibitor 9 can be used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> c-Myc

[In Vitro]

c-Myc inhibitor 9 对 Myc 具有活性，在表达 c-Myc 的 A549 细胞中，logEC50 值 ≥6[1]。

[In Vivo]

c-Myc inhibitor 9 (3 mg/kg；腹腔注射，每周 2 次，49 天) 有效抑制 A549 异种移植裸鼠的肿瘤生长[1]。 Animal Model: NMRI female nude mice with A549 xenografts[1] Dosage: 3 mg/kg Administration: Intraperitoneal injection; 3 mg/kg, twice a week, for 49 days Result: Reduced tumor volume.

[References]

[1]. Sheppard, David William, et al. Preparation of heteroaryl compounds as c-MYC mRNA translation modulators and uses thereof in the treatment of cancer. WO2022150316. 2022.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H31N5OS

[ Molecular Weight ]:
473.63

Related Compounds