SCAL-266

Names

[ Name ]:
SCAL-266

Biological Activity

[Description]:

SCAL-266 is a potent mitochondrial complex I (CI) inhibitor with IC50 of 0.83 μM. SCAL-266 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-266 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Yang Zhou, et al. Synthesis and biological evaluation of novel pyrazole amides as potent mitochondrial complex I inhibitors. Eur J Med Chem. 2023 Oct 5;258:115576.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₈F₃N₅O₂

[ Molecular Weight ]:
511.54

Related Compounds

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