Lamiide

Names

[ Name ]:
Lamiide

[Synonym ]:
Methyl (1S,4aR,6S,7R,7aS)-1-(β-D-glucopyranosyloxy)-4a,6,7-trihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate
Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-4a,6,7-trihydroxy-7-methyl-, methyl ester, (1S,4aR,6S,7R,7aS)-

Biological Activity

[Description]:

Lamiide, an orally active iridoid compound, can be found in Bouchea fluminensis leaves. Lamiide exhibits anti-inflammatory and anti-lipoperoxidative activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Lamiide inhibits rat-brain phospholipid peroxidation, with an IC50 of 0.92 mM[1].

[In Vivo]

Lamiide (12.5-100 mg/kg; p.o. 30 min before Carrageenin injection) dose-dependently reduces Carrageenin-induced edema[1]. Animal Model: Female Wistar rats (8-weeks old, 150-200 g) were injected with Carrageenin in the subplantar aponeurosis of the right hind paw[1] Dosage: 12.5, 25, 50, 100 mg/kg Administration: P.o. 30 min before Carrageenin injection Result: Reduced Carrageenin-induced edema, with an ED50 of 62.3 mg/kg.

[References]

[1]. Delaporte RH, et, al. Anti-inflammatory activity and lipid peroxidation inhibition of iridoid lamiide isolated from Bouchea fluminensis (Vell.) Mold. (Verbenaceae). J Ethnopharmacol. 2002 Oct;82(2-3):127-30.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
667.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₆O₁₂

[ Molecular Weight ]:
422.381

[ Flash Point ]:
237.8±25.0 °C

[ Exact Mass ]:
422.142426

[ PSA ]:
195.60000

[ LogP ]:
-3.03

[ Vapour Pressure ]:
0.0±4.6 mmHg at 25°C

[ Index of Refraction ]:
1.644

[ Storage condition ]:
?20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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