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HIV-1 inhibitor-54

Names

[ CAS No. ]:
2771211-71-1

[ Name ]:
HIV-1 inhibitor-54

Biological Activity

[Description]:

HIV-1 inhibitor-54 is a potent HIV-1 inhibitor. HIV-1 inhibitor-54 has anti-HIV activity in MT-4 cells against WT HIV-1 (strain IIIB) with an EC50 value of 0.032 μM. HIV-1 inhibitor-54 can be used for the research of virus infection[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1


[In Vitro]

HIV-1 inhibitor-54 (compound 4c) 对 HIV-1 突变体 E138K、K103 N、Y188L、Y181C、F227L+V106A 和 L100I 表现出较强的抗逆转录酶活性，其 EC50 值分别为 0.080 , 0.52, 0.67, 0.84, 2.7 和 3.3 μM[1]。 HIV-1 inhibitor-54 抑制野生型 HIV-1 逆转录的活性，IC50 值为 12 μM[1]。

[References]

[1]. Ming W, et al. Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities. Eur J Med Chem. 2023 Feb 15;248:115114.  

Chemical & Physical Properties

[ Molecular Formula ]:
C27H30N6O4S

[ Molecular Weight ]:
534.63

Related Compounds