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STING PROTAC SP23

Names

[ CAS No. ]:
2762552-74-7

[ Name ]:
STING PROTAC SP23

Biological Activity

[Description]:

SP23 is a STING protein degrader (PROTAC) based on a small-molecule STING inhibitor (C-170) and pomalidomide (a CRBN ligand), shows degradation potency with DC50 of 3.2 uM.SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway.

[References]

1. Jin Liu, et al. J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.1c01948.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H33N7O10

[ Molecular Weight ]:
699.677


Related Compounds

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