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STING Agonist 1a

Names

[ CAS No. ]:
652142-94-4

[ Name ]:
STING Agonist 1a

[Synonym ]:
4-Chloro-1-(2-chloro-6-methoxy-3-quinolinyl)[1,2,4]triazolo[4,3-a]quinoxaline
[1,2,4]Triazolo[4,3-a]quinoxaline, 4-chloro-1-(2-chloro-6-methoxy-3-quinolinyl)-
MFCD03861727
STING Agonist 1a

Biological Activity

[Description]:

STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Immunology/Inflammation >> STING

[In Vitro]

STING agonist-16 (1a) (0-100 μM, 6 h) can promote mRNA expression of IFNβ, CXCL-10 and IL-6 in a dose-dependent manner with no significant cytotoxic effect up to 100 μM in human myeloid leukemia mononuclear cells (THP1)[1]. STING agonist-16 (1a) (50 μM, 2 h) significantly induces the phosphorylation of STING, TANK-binding kinases1 (TBK1) and interferon regulatory factor 3 (IRF3) in THP1 cells[1]. STING agonist-16 (1a) activates secretory alkaline phosphatase (SEAP) in a dose-dependent manner with an EC50 value of 16.77 μM while 2'3'-cGAMP acts with an EC50 value of 9.212 μM[1].

[References]

[1]. Hui Hou, et al. Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screening. Bioorg Chem. 2020 Jul;100:103958.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C19H11Cl2N5O

[ Molecular Weight ]:
396.229

[ Exact Mass ]:
395.034058

[ LogP ]:
4.40

[ Index of Refraction ]:
1.772

Related Compounds