CD33 splicing modulator 1 hydrochloride

Names

[ CAS No. ]:
2762547-06-6

[ Name ]:
CD33 splicing modulator 1 hydrochloride

Biological Activity

[Description]:

CD33 splicing modulator 1 (Compound 1) hydrochloride is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity. CD33 splicing modulator 1 hydrochloride increases exon 2 skipping in cellular mRNA pools. CD33 splicing modulator 1 hydrochloride has the potential for the research of neurodegenerative disease including Alzheimer's disease[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Chappie TA, et al. Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators. ACS Med Chem Lett. 2022;13(1):55-62.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H26ClFN6O

[ Molecular Weight ]:
480.96

Related Compounds

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