ZDLD20

Names

[ Name ]:
ZDLD20

Biological Activity

[Description]:

ZDLD20, a β-carboline, is orally active and selective CDK4/CycD3 inhibitor with an IC50 value of 6.51 μM. ZDLD20 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD20 exhibits potent anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK4/CycD3:6.51 μM (IC50)

[References]

[1]. Deping Li, et al. Facile synthesis of C1-substituted β-carbolines as CDK4 inhibitors for the treatment of cancer. Bioorg Chem. 2022 Apr;121:105659.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₂N₆O

[ Molecular Weight ]:
386.45

Related Compounds

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