Skp2 inhibitor 2

Names

[ CAS No. ]:
2760612-77-7

[ Name ]:
Skp2 inhibitor 2

Biological Activity

[Description]:

Skp2 inhibitor 2 (14f) is an inhibitor of F-box protein S-phase kinase-associated protein 2 (Skp2), with an IC50 value of 10.2 μM (Skp2-Cks1). Skp2 is a part of cullin-RING ligases, which recruits and ubiquitinates substrates, involving in proteolytic and non-proteolytic process[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme

[Target]

cullin-RING ligases[1]


[References]

[1]. Zhang K, et al. Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Jun 8;66(11):7221-7242.  

Chemical & Physical Properties

[ Molecular Formula ]:
C27H32N4O

[ Molecular Weight ]:
428.57

Related Compounds