2760612-77-7

2760612-77-7 structure

Name: Skp2 inhibitor 2
Chemical Name: Skp2 inhibitor 2
CAS Number: 2760612-77-7
Molecular Formula: C₂₇H₃₂N₄O
Molecular Weight: 428.57
Catalog: Signaling Pathways Metabolic Enzyme/Protease E1/E2/E3 Enzyme
Create Date: 2023-09-17 19:53:03
Modify Date: 2024-01-17 11:30:04
Skp2 inhibitor 2 (14f) is an inhibitor of F-box protein S-phase kinase-associated protein 2 (Skp2), with an IC50 value of 10.2 μM (Skp2-Cks1). Skp2 is a part of cullin-RING ligases, which recruits and ubiquitinates substrates, involving in proteolytic and non-proteolytic process[1].

Name	Skp2 inhibitor 2

Description	Skp2 inhibitor 2 (14f) is an inhibitor of F-box protein S-phase kinase-associated protein 2 (Skp2), with an IC50 value of 10.2 μM (Skp2-Cks1). Skp2 is a part of cullin-RING ligases, which recruits and ubiquitinates substrates, involving in proteolytic and non-proteolytic process[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme
Target	cullin-RING ligases[1]
References	[1]. Zhang K, et al. Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Jun 8;66(11):7221-7242.

Molecular Formula	C₂₇H₃₂N₄O
Molecular Weight	428.57