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Skp2 inhibitor 1

Names

[ CAS No. ]:
2760612-63-1

[ Name ]:
Skp2 inhibitor 1

Biological Activity

[Description]:

Skp2 inhibitor 1 (compound 14i) is a potent and selective Skp2 inhibitor against the Skp2-Cks1 interaction with an IC50 of 2.8 μM. Skp inhibitor 1 exhibits anticancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme

[Target]

Growth arrest-specific protein 6(Gas6)-Cell Cyclin Kinase Subunit 1(Cks1) [1]IC50：2.8 μM(Growth arrest-specific protein 6,Gas6; Cell Cyclin Kinase Subunit 1,Cks1)[1]


[References]

[1]. Zhang K, et al. Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Jun 8;66(11):7221-7242.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H23ClN4O

[ Molecular Weight ]:
406.91

Related Compounds