Heterophdoid A

Names

[ Name ]:
Heterophdoid A

Biological Activity

[Description]:

Heterophdoid A (Compound 1) is an anti-inflammatory agent. Heterophdoid A inhibits NO production with an IC50 of 5.93 μM in BV-2 cells[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

NO production:5.93 μM (IC50)

COX-2

[In Vitro]

Heterophdoid A (Compound 1) (0-10 μM) decreases the expression of iNOS and COX-2[1].

[In Vivo]

Heterophdoid A (Compound 1) (0-10 μM) suppresses ROS and NO dose-dependently in a zebrafish model[1].

[References]

[1]. Wu P, et al. Natural iridoids from Patrinia heterophylla showing anti-inflammatory activities in vitro and in vivo. Bioorg Chem. 2020 Nov;104:104331.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₄₂O₁₀

[ Molecular Weight ]:
514.61

Related Compounds

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