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1-Aminocyclohexanecarboxylic acid

Names

[ CAS No. ]:
2756-85-6

[ Name ]:
1-Aminocyclohexanecarboxylic acid

[Synonym ]:
1-amino-cyclohexane-1-carboxylic acid
Cyclohexanecarboxylic acid,1-amino
a-Aminocyclohexanecarboxylic acid
1-Aminocyclohexanecarboxylic acid
1-amino-1-cyclo-hexanecarboxylic acid
1-amino-1-cyclohexane carboxylic acid
Homocycloleucine
1-aminocyclohexane-1-carboxylic acid
1-amino-1-cyclohexylcarboxylic acid
1-amino-1-cyclohexanecarboxylic acid
MFCD00001487
Cyclohexanecarboxylic acid, 1-amino-
1-Amino-1-CyclohexanecarboxylicAcid
EINECS 220-411-0

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
272.3±23.0 °C at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C7H13NO2

[ Molecular Weight ]:
143.184

[ Flash Point ]:
118.5±22.6 °C

[ Exact Mass ]:
143.094635

[ PSA ]:
63.32000

[ LogP ]:
0.51

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.509

[ Storage condition ]:
Store at RT.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GU8393000
CHEMICAL NAME :
Cyclohexanecarboxylic acid, 1-amino-
CAS REGISTRY NUMBER :
2756-85-6
BEILSTEIN REFERENCE NO. :
2355692
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H13-N-O2
MOLECULAR WEIGHT :
143.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 5,108,1960

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GU8393000

[ HS Code ]:
2922499990

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex.

J. Med. Chem. 52 , 5093-107, (2009)

Retaining agonistic activity at the glycine coagonist site of the NMDA receptor in molecules derived from glycine or d-serine has proven to be difficult because in the vicinity of the alpha-amino acid...

Application of 1-aminocyclohexane carboxylic acid to protein nanostructure computer design.

J. Chem. Inf. Model. 48(2) , 333-43, (2008)

Conformationally restricted amino acids are promising candidates to serve as basic pieces in redesigned protein motifs which constitute the basic modules in synthetic nanoconstructs. Here we study the...

Influence of 1-aminocyclohexane-1-carboxylic acid in position 2 or 3 of AVP and its analogues on their pharmacological properties.

J. Pept. Res. 62(2) , 70-7, (2003)

In this study we describe the synthesis and some pharmacological properties of seven new analogues of arginine vasopressin (AVP) substituted in position 2 or 3 with 1-aminocyclohexane-1-carboxylic aci...


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