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SARS-CoV-2 Mpro-IN-9

Names

[ CAS No. ]:
2754370-99-3

[ Name ]:
SARS-CoV-2 Mpro-IN-9

Biological Activity

[Description]:

SARS-CoV-2 Mpro-IN-9 (compound c7) is a nonpeptidic, noncovalent SARS-CoV-2 Mpro inhibitor (IC50=0.085 μM), with improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties. SARS-CoV-2 Mpro-IN-9 inhibits viral replication (EC50=1.10 μM) in SARS-CoV-2-infected Vero E6 cells, while exhibits low cytotoxic effects (CC50>50 μM)[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

IC50: 0.085 μM (SARS-CoV-2), EC50: 1.10 μM (viral replication)[1]


[References]

[1]. Zhang K, et al. Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro). Eur J Med Chem. 2023 Sep 5;257:115487.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H14N2O4

[ Molecular Weight ]:
346.34

Related Compounds