2754370-99-3

2754370-99-3 structure

Name: SARS-CoV-2 Mpro-IN-9
Chemical Name: SARS-CoV-2 Mpro-IN-9
CAS Number: 2754370-99-3
Molecular Formula: C₂₀H₁₄N₂O₄
Molecular Weight: 346.34
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2023-11-25 17:04:21
Modify Date: 2024-01-13 23:20:04
SARS-CoV-2 Mpro-IN-9 (compound c7) is a nonpeptidic, noncovalent SARS-CoV-2 Mpro inhibitor (IC50=0.085 μM), with improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties. SARS-CoV-2 Mpro-IN-9 inhibits viral replication (EC50=1.10 μM) in SARS-CoV-2-infected Vero E6 cells, while exhibits low cytotoxic effects (CC50>50 μM)[1].

Name	SARS-CoV-2 Mpro-IN-9

Description	SARS-CoV-2 Mpro-IN-9 (compound c7) is a nonpeptidic, noncovalent SARS-CoV-2 Mpro inhibitor (IC50=0.085 μM), with improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties. SARS-CoV-2 Mpro-IN-9 inhibits viral replication (EC50=1.10 μM) in SARS-CoV-2-infected Vero E6 cells, while exhibits low cytotoxic effects (CC50>50 μM)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	IC50: 0.085 μM (SARS-CoV-2), EC50: 1.10 μM (viral replication)[1]
References	[1]. Zhang K, et al. Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro). Eur J Med Chem. 2023 Sep 5;257:115487.

Molecular Formula	C₂₀H₁₄N₂O₄
Molecular Weight	346.34