4alpha-PDD

Names

[ Name ]:
4alpha-PDD

[Synonym ]:
4a-phorbol 12,13-didecanoate
Phorbol-9,9a-didecanoat
4a-phenyl-4,4a,5,6,7,8-hexahydro-2H-cinnolin-3-one

Biological Activity

[Description]:

4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca2+ influx[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[References]

[1]. Hiromi Tsushima, et al. Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle. Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1736-41.

[2]. Lori Birder, et al. Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther. 2007 Oct;323(1):227-35.

Chemical & Physical Properties

[ Density]:
1.14g/cm3

[ Boiling Point ]:
734.2ºC at 760mmHg

[ Molecular Formula ]:
C₄₀H₆₄O₈

[ Molecular Weight ]:
672.93100

[ Flash Point ]:
212.4ºC

[ Exact Mass ]:
672.46000

[ PSA ]:
130.36000

[ LogP ]:
7.31330

[ Vapour Pressure ]:
6.92E-25mmHg at 25°C

[ Index of Refraction ]:
1.546

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H310 + H330-H334-H351

[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
26/27/28-40-43

[ Safety Phrases ]:
36/37/39-45

[ RIDADR ]:
UN 2811 6.1/PG 2

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells.

Pflugers Arch. 464(3) , 261-72, (2012)

Pulmonary hypertension, the main disease of the pulmonary circulation, is characterized by an increase in pulmonary vascular resistance, involving proliferation and migration of pulmonary arterial smo...

Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium.

Am. J. Physiol. Lung Cell. Mol. Physiol. 297(4) , L650-7, (2009)

Pulmonary vascular endothelial cells express a variety of ion channels that mediate Ca(2+) influx in response to diverse environmental stimuli. However, it is not clear whether Ca(2+) influx from disc...

Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication.

Hypertension 53(2) , 228-35, (2009)

To test the hypothesis that activation of the transient receptor potential vanilloid 4 (TRPV4) channel conveys a hypotensive effect that is enhanced during salt load, male Wistar rats fed a normal-sod...