Dim16

Names

[ Name ]:
Dim16

Biological Activity

[Description]:

Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC50 value of 19 nM for PCSK9. Dim16 inhibits PCSK9-LDLR binding with an IC50 value of 0.8 nM. Dim16 increases LDL uptake in HepG2 cells[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Metabolic Disease

[Target]

19 nM (PCSK9)[1]

[References]

[1]. Lammi C, et al. Computational Design, Synthesis, and Biological Evaluation of Diimidazole Analogues Endowed with Dual PCSK9/HMG-CoAR-Inhibiting Activity. J Med Chem. 2023 Jun 22;66(12):7943-7958.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₈IN₅

[ Molecular Weight ]:
583.55

Related Compounds

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