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2743448-32-8

2743448-32-8 structure

2743448-32-8 structure

Name: Dim16
Chemical Name: Dim16
CAS Number: 2743448-32-8
Molecular Formula: C₂₉H₃₈IN₅
Molecular Weight: 583.55
Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
Create Date: 2023-10-03 18:57:07
Modify Date: 2025-08-29 18:33:11
Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC50 value of 19 nM for PCSK9. Dim16 inhibits PCSK9-LDLR binding with an IC50 value of 0.8 nM. Dim16 increases LDL uptake in HepG2 cells[1].

Name	Dim16

Description	Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC50 value of 19 nM for PCSK9. Dim16 inhibits PCSK9-LDLR binding with an IC50 value of 0.8 nM. Dim16 increases LDL uptake in HepG2 cells[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Metabolic Disease
Target	19 nM (PCSK9)[1]
References	[1]. Lammi C, et al. Computational Design, Synthesis, and Biological Evaluation of Diimidazole Analogues Endowed with Dual PCSK9/HMG-CoAR-Inhibiting Activity. J Med Chem. 2023 Jun 22;66(12):7943-7958.

Molecular Formula	C₂₉H₃₈IN₅
Molecular Weight	583.55

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