SW-101
Names
[ CAS No. ]:
2738688-82-7
[ Name ]:
SW-101
Biological Activity
[Description]:
SW-101 (SW101) is a potent, selective HDAC6 inhibitor with IC50 of 0.7 nM, >200-fold selectivity over HDAC1/2/3.SW-101 possesses excellent HDAC6 potency and selectivity, together with markedly improved metabolic stability and druglike properties compared to SW-100.SW-101 treatment elevates the impaired level of acetylated α-tubulin in the distal sciatic nerve, counteracts progressive motor dysfunction, and ameliorates neuropathic symptoms in a CMT2A mouse model bearing mutant MFN2.
[References]
1. Sida Shen, et al. J Med Chem. 2021 Apr 22;64(8):4810-4840.
Chemical & Physical Properties
[ Molecular Formula ]:
C18H19N3O3
[ Molecular Weight ]:
325.368