CDK9-IN-29

Names

[ CAS No. ]:
2737262-24-5

[ Name ]:
CDK9-IN-29

Biological Activity

[Description]:

CDK9-IN-29 (compound Z11) is a potent CDK9 inhibitor (IC50 = 3.20 nM) with good kinase selectivity. CDK9-IN-29 inhibits cell proliferation and induces apoptosis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[References]

[1]. Tizhi Wu, et al. Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer. J Med Chem. 2023.  

Chemical & Physical Properties

[ Molecular Formula ]:
C29H33F2N5O4

[ Molecular Weight ]:
553.60

Related Compounds