DS45500853

Names

[ Name ]:
DS45500853

Biological Activity

[Description]:

DS45500853 is an estrogen-related receptor α (ERRα) agonist. DS45500853 inhibits the binding between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain (LBD; 1.2 μM) with an >IC50 value of 0.80 μM. DS45500853 can be used for the research of metabolic disorders, including type 2 diabetes mellitus (T2DM)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Metabolic Disease

[Target]

ERRα

[References]

[1]. Shinozuka T, et al. Discovery of a Novel Class of ERRα Agonists. ACS Med Chem Lett. 2021 Apr 21;12(5):817-821.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₀O₃

[ Molecular Weight ]:
284.35

Related Compounds

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